2483831-27-0
Chemical Structure
3-epi-25-Hydroxy Vitamin D3-d6
- CAS No.: 2483831-27-0
- Formula:C27H38D6O2
- Molecular Weight:406.67
IUPAC Name: (R,Z)-3-(2-((1R,3aS,7aR,E)-1-((R)-6-hydroxy-6-(methyl-d3)heptan-2-yl-7,7,7-d3)-7a-methyloctahydro-4H-inden-4-ylidene)ethylidene)-4-methylenecyclohexan-1-ol
InChIKey: JWUBBDSIWDLEOM-IBDKAFOJSA-N
SMILES: C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCCC(O)(C([2H])([2H])[2H])C([2H])([2H])[2H])([H])/C(CCC1)=C/C=C3C(CC[C@H](C\3)O)=C
Biological Activity: 3-epi-25-Hydroxy Vitamin D3-d6 is the deuterium labeled 3-epi-25-Hydroxy Vitamin D3 (HY-142140)[1]. 3-epi-25-Hydroxy Vitamin D3 is the vitamin D metabolite, while vitamin D metabolism highly dependent on macrophage polarization. The C3-epimerase pathway for vitamin D is active in macrophages[2].
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3-epi-25-Hydroxy Vitamin D3-d6 | 3-epi-25-Hydroxy Vitamin D3-d6 is the deuterium labeled 3-epi-25-Hydroxy Vitamin D3 (HY-142140). 3-epi-25-Hydroxy Vitamin D3 is the vitamin D metabolite, while vitamin D metabolism highly dependent on macrophage polarization. The C3-epimerase pathway for vitamin D is active in macrophages. | |||||||||||||||||||||
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3-epi-Calcifediol (Standard) | ≥98% | 3-epi-Calcifediol (Standard) is the analytical standard of 3-epi-Calcifediol. This product is intended for research and analytical applications. 3-epi-25-hydroxy Vitamin D3 is the C-3 epimer of 25-hydroxy vitamin D3.1 Dietary administration of 3-epi-25-hydroxy vitamin D3 (0.5 and 1 IU/g) decreases levels of serum parathyroid hormone (PTH) in male, but not female, weanling rats. | ||||||||||||||||||||
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3-epi-Calcifediol-13C5 | 3-Epi-25-hydroxyvitamin D3-13C5 is the 13C labeled 3-Epi-25-hydroxyvitamin D3. | |||||||||||||||||||||
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3-epi-Calcifediol-d3 | 3-Epi-25-Hydroxyvitamin D3-d3 is the deuterium labeled 3-Epi-25-Hydroxyvitamin D3. | |||||||||||||||||||||
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3-epi-Calcifediol | 3-epi-25-hydroxy Vitamin D3 is the C-3 epimer of 25-hydroxy vitamin D3.1 Dietary administration of 3-epi-25-hydroxy vitamin D3 (0.5 and 1 IU/g) decreases levels of serum parathyroid hormone (PTH) in male, but not female, weanling rats. | |||||||||||||||||||||
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- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
- [2]. Nygaard RH, et al'. Metabolism of 25-Hydroxy-Vitamin D in Human Macrophages Is Highly Dependent on Macrophage Polarization. Int J Mol Sci. 2022 Sep 19;23(18):10943. [Content Brief]
