2508-89-6
2508-89-6
Chemical Structure
Duazomycin
Synonym(s): Duazomycin A
- CAS No.: 2508-89-6
- Formula:C8H11N3O4
- Molecular Weight:213.19
IUPAC Name: (S)-2-acetamido-6-diazo-5-oxohexanoic acid
InChIKey: WBSWOKCKZUNHQV-ZETCQYMHSA-N
SMILES: [N-]=[N+]=CC(CC[C@@H](C(O)=O)NC(C)=O)=O
Biological Activity: Duazomycin A is a glutamine antagonist. Duazomycin A can significantly enhance the effectiveness of 6-Mercaptopurine (6-MP) (HY-13677) in experimental allergic encephalomyelitis (EAE) without increasing toxicity[1][2].
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Duazomycin | Duazomycin A is a glutamine antagonist. Duazomycin A can significantly enhance the effectiveness of 6-Mercaptopurine (6-MP) (HY-13677) in experimental allergic encephalomyelitis (EAE) without increasing toxicity. | |||||||||||||||||||||
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References
- [1]. Vogel C L, et al. Enhanced suppression of experimental allergic encephalomyelitis by combination chemotherapy with duazomycin-A and 6-mercaptopurine[J]. Proceedings of the Society for Experimental Biology and Medicine, 1969, 131(1): 251-256. [Content Brief]
- [2]. Rosenberg S, et al. Enhanced Suppression of the Secondary Immune Response by Combination of 6-Mercaptopurine ‘Duazomycin A’[J]. Nature, 1963, 199(4898): 1101-1102.
Keywords
