2541626-73-5
Chemical Structure
Aurora-A ligand 1
- CAS No.: 2541626-73-5
- Formula:C21H23N5O3
- Molecular Weight:393.44
InChIKey: QOYBWPMLFXVESV-UHFFFAOYSA-N
SMILES: O=C(N(C)C)C(N1C2CCCC2)=CC3=C1N=C(NC4=CC=C(C(O)=O)C=C4)N=C3
Biological Activity: Aurora-A ligand 1 is a high-affinity and specific Aurora-A inhibitor with a dissociation constant (Kd) value of 0.85 nM. Aurora-A ligand 1 can serve as a ligand for target protein (Ligands for Target Protein for PROTAC) for the development of PROTAC Aurora-A degraders with antitumor activity. Aurora-A ligand 1 can be used for the synthesis of HLB-0532259 (HY-168439). HLB-0532259 shows anti-tumor activity against neuroblastoma[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Aurora-A ligand 1 | 98.75% | Aurora-A ligand 1 is a high-affinity and specific Aurora-A inhibitor with a dissociation constant (Kd) value of 0.85 nM. Aurora-A ligand 1 can serve as a ligand for target protein (Ligands for Target Protein for PROTAC) for the development of PROTAC Aurora-A degraders with antitumor activity. Aurora-A ligand 1 can be used for the synthesis of HLB-0532259 (HY-168439). HLB-0532259 shows anti-tumor activity against neuroblastoma. | ||||||||||||||||||||
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Keywords
