2571578-55-5
Chemical Structure
TCMDC-135051 TFA
- CAS No.: 2571578-55-5
- Formula:C31H34F3N3O5
- Molecular Weight:585.61
IUPAC Name: 2,2,2-trifluoroacetic acid compound with 4-(2-(5-((diethylamino)methyl)-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)-2-isopropylbenzoic acid (1:1)
InChIKey: QQIOPVVOIRCNFY-UHFFFAOYSA-N
SMILES: O=C(O)C1=CC=C(C2=C3C(NC(C4=C(OC)C=CC(CN(CC)CC)=C4)=C3)=NC=C2)C=C1C(C)C.OC(C(F)(F)F)=O
Biological Activity: TCMDC-135051 TFA is a highly selective and potent protein kinase PfCLK3 inhibitor with low off-target toxicity. TCMDC-135051 TFA prevents trophozoite-to-schizont transition, disrupts transcription and reduces transmission to the mosquito vector. TCMDC-135051 TFA has antiparasiticidal activity (EC50=320 nM)[1].
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TCMDC-135051 TFA | TCMDC-135051 TFA is a highly selective and potent protein kinase PfCLK3 inhibitor with low off-target toxicity. TCMDC-135051 TFA prevents trophozoite-to-schizont transition, disrupts transcription and reduces transmission to the mosquito vector. TCMDC-135051 TFA has antiparasiticidal activity (EC50=320 nM). | |||||||||||||||||||||
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Keywords
