2582758-61-8
2582758-61-8
Chemical Structure
MIF-IN-6
- CAS No.: 2582758-61-8
- Formula:C18H13ClFN5O2
- Molecular Weight:385.78
IUPAC Name: 5-chloro-N-((1-(3-fluoro-4-hydroxyphenyl)-1H-1,2,3-triazol-4-yl)methyl)-1H-indole-2-carboxamide
InChIKey: AXXDWEHJHMJKTF-UHFFFAOYSA-N
SMILES: O=C(C1=CC2=CC(Cl)=CC=C2N1)NCC3=CN(N=N3)C4=CC(F)=C(C=C4)O
Biological Activity: MIF-IN-6 (compound 2d) is a potent macrophage migration inhibitory factor (MIF) inhibitor with an IC50 of 1.4 μM and a Ki value of 0.96 μM, respectively. MIF-IN-6 attenuates MIF-induced ERK phosphorylation and inhibits proliferation of A549 cells[1].
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MIF-IN-6 | MIF-IN-6 (compound 2d) is a potent macrophage migration inhibitory factor (MIF) inhibitor with an IC50 of 1.4 μM and a Ki value of 0.96 μM, respectively. MIF-IN-6 attenuates MIF-induced ERK phosphorylation and inhibits proliferation of A549 cells. | |||||||||||||||||||||
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References
Keywords
