259188-38-0
Chemical Structure
Rebimastat
Synonym(s): BMS 275291
- CAS No.: 259188-38-0
- Formula:C23H41N5O5S
- Molecular Weight:499.67
IUPAC Name: (R)-N-((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-2-((S)-2-mercapto-4-(3,4,4-trimethyl-2,5-dioxoimidazolidin-1-yl)butanamido)-4-methylpentanamide
InChIKey: GTXSRFUZSLTDFX-HRCADAONSA-N
SMILES: CNC([C@H](C(C)(C)C)NC([C@H](CC(C)C)NC([C@@H](S)CCN1C(C(C)(N(C1=O)C)C)=O)=O)=O)=O
Biological Activity: Rebimastat (BMS 275291) is an orally active, broad-spectrum MMP inhibitor and non-peptide collagen mimetic. Rebimastat has some selectivity because it does not inhibit all MMP activities. Rebimastat can be used in the research of colorectal cancer[1][2].
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Rebimastat | Rebimastat (BMS 275291) is an orally active, broad-spectrum MMP inhibitor and non-peptide collagen mimetic. Rebimastat has some selectivity because it does not inhibit all MMP activities. Rebimastat can be used in the research of colorectal cancer. | |||||||||||||||||||||
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- [1]. Sobirzhanovna B N. New Aspects of Pathology and Norms of Matrix Metalloproteinases. Web of Medicine: Journal of Medicine, Practice and Nursing, 2024, 2(3): 34-37.
- [2]. Peng H, et al. Prediction of the survival status and tumor microenvironment in colorectal cancer through genotyping analysis based on toll-like receptors. Saudi J Gastroenterol. 2024 Jul 1;30(4):243-251. [Content Brief]
Keywords
