2599098-78-7
Chemical Structure
BCL-XL-IN-5
- CAS No.: 2599098-78-7
- Formula:C36H38N8O2S
- Molecular Weight:646.80
InChIKey: YDPDDZUZWPNIPU-UHFFFAOYSA-N
SMILES: O=C(O)C1=NC(N2CCCC3=C(C)C(NC4=NC5=CC=CC=C5S4)=NN=C32)=CC=C1C6=C(C)N(CC78CC9CC(C8)CC(C9)C7)N=C6
Biological Activity: BCL-XL-IN-5 is an orally active, highly selective BH3-mimetic BCL-XL inhibitor with a cKi of 7.96 pM. BCL-XL-IN-5 triggers caspase-3 activation and robust PARP cleavage to initiate apoptosis in BCL-XL-dependent MOLT-4 T-cell acute lymphoblastic leukemia cells. BCL-XL-IN-5 serves as a potent selective probe for investigating BCL-XL-dependent malignancies, such as acute lymphoblastic leukemia[1].
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BCL-XL-IN-5 | BCL-XL-IN-5 is an orally active, highly selective BH3-mimetic BCL-XL inhibitor with a cKi of 7.96 pM. BCL-XL-IN-5 triggers caspase-3 activation and robust PARP cleavage to initiate apoptosis in BCL-XL-dependent MOLT-4 T-cell acute lymphoblastic leukemia cells. BCL-XL-IN-5 serves as a potent selective probe for investigating BCL-XL-dependent malignancies, such as acute lymphoblastic leukemia. | |||||||||||||||||||||
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Keywords
