2636839-90-0
Chemical Structure
p53 Activator 3
- CAS No.: 2636839-90-0
- Formula:C30H37F3N4O4S
- Molecular Weight:606.70
IUPAC Name: 2-(2-((3-(4-(((1r,4r)-4-(dimethylamino)cyclohexyl)amino)-1-(2,2,2-trifluoroethyl)-1H-indol-2-yl)prop-2-yn-1-yl)amino)-5-(methylsulfonyl)phenoxy)ethan-1-ol
InChIKey: NSHFHMCYOOBDBY-HZCBDIJESA-N
SMILES: OCCOC1=CC(S(C)(=O)=O)=CC=C1NCC#CC2=CC3=C(C=CC=C3N[C@@H]4CC[C@H](CC4)N(C)C)N2CC(F)(F)F
Biological Activity: p53 Activator 3 (compound 87A) is a potent p53 activator with a SC150 value of <0.05 mM. p53 Activator 3 can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA. p53 Activator 3 shows anti-tumor activity[1]. p53 Activator 3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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p53 Activator 3 | 95.67% | p53 Activator 3 (compound 87A) is a potent p53 activator with a SC150 value of <0.05 mM. p53 Activator 3 can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA. p53 Activator 3 shows anti-tumor activity. p53 Activator 3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | ||||||||||||||||||||
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Keywords
