2640753-22-4
2640753-22-4
Chemical Structure
ONO-9517601
Synonym(s): VU6022856
- CAS No.: 2640753-22-4
- Formula:C25H24ClN5O2
- Molecular Weight:461.94
InChIKey: SEHBAHPVZNGRAM-UHFFFAOYSA-N
SMILES: CC1=C(N=CC(C#CC2=CC=CC=C2)=C1)NC(C3=C(C=NN3C4CCN(CC4)C(C)=O)Cl)=O
Biological Activity: ONO-9517601 is a potent, orally active, selective and CNS penetrant dual TREK-1/TREK-2 inhibitor (TREK-1 IC50= 0.067 μM, TREK-2 IC50= 0.23 μM). ONO-9517601 displays robust efficacy in an MK-801 (HY-15084B) challenge rat novel object recognition (NOR) paradigm. ONO-9517601 can be used for research on neurological and cognitive disorders[1].
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ONO-9517601 | ONO-9517601 is a potent, orally active, selective and CNS penetrant dual TREK-1/TREK-2 inhibitor (TREK-1 IC50= 0.067 μM, TREK-2 IC50= 0.23 μM). ONO-9517601 displays robust efficacy in an MK-801 (HY-15084B) challenge rat novel object recognition (NOR) paradigm. ONO-9517601 can be used for research on neurological and cognitive disorders. | |||||||||||||||||||||
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References
Keywords
