2643334-76-1
2643334-76-1
Chemical Structure
ROCK-IN-9
- CAS No.: 2643334-76-1
- Formula:C20H20FN5O2
- Molecular Weight:381.40
InChIKey: YCJDCYVAPRKXDT-UHFFFAOYSA-N
SMILES: O=C(N1C2=C(CC1)C=C(C3=CNN=C3N)C(F)=C2)NCC4=CC(OC)=CC=C4
Biological Activity: ROCK-IN-9 (Compound T345) is a ROCK inhibitor. ROCK-IN-9 shows cytotoxicity in HepG2 cell, with an IC50 of 40.8 μM. ROCK-IN-9 has good pharmacokinetic properties in mice, and shows high in vivo exposure and oral bioavailability at lower doses[1].
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ROCK-IN-9 | ROCK-IN-9 (Compound T345) is a ROCK inhibitor. ROCK-IN-9 shows cytotoxicity in HepG2 cell, with an IC50 of 40.8 μM. ROCK-IN-9 has good pharmacokinetic properties in mice, and shows high in vivo exposure and oral bioavailability at lower doses. | |||||||||||||||||||||
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References
Keywords
