2648808-69-7
Chemical Structure
KRAS G12C inhibitor 43
- CAS No.: 2648808-69-7
- Formula:C33H35N7O3
- Molecular Weight:577.68
IUPAC Name: 2-((S)-1-acryloyl-4-(7-(3-methoxynaphthalen-1-yl)-2-(((S)-1-methylpyrrolidin-2-yl)methoxy)pyrido[2,3-d]pyrimidin-4-yl)piperazin-2-yl)acetonitrile
InChIKey: JXYVRMVMAUIZEY-ZEQRLZLVSA-N
SMILES: C=CC(N1CCN(C[C@@H]1CC#N)C2=C3C=CC(C4=C5C=CC=CC5=CC(OC)=C4)=NC3=NC(OC[C@@H]6CCCN6C)=N2)=O
Biological Activity: KRAS G12C inhibitor 43 (compound 59) is a potent KRAS G12C inhibitor. KRAS G12C inhibitor 43 shows antimigration and anti-proliferative activity with IC50s of 0.001-1 µM, >1 µM, >1 µM for H358, A549, HCC cells ,respectively[1].
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KRAS G12C inhibitor 43 | KRAS G12C inhibitor 43 (compound 59) is a potent KRAS G12C inhibitor. KRAS G12C inhibitor 43 shows antimigration and anti-proliferative activity with IC50s of 0.001-1 µM, >1 µM, >1 µM for H358, A549, HCC cells ,respectively. | |||||||||||||||||||||
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Keywords
