2667681-71-0
Chemical Structure
IRAK4-IN-14
- CAS No.: 2667681-71-0
- Formula:C25H28FN9O
- Molecular Weight:489.55
IUPAC Name: 7-fluoro-4-(1-methylcyclopropoxy)-N-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)-6-(2-methylpyrimidin-5-yl)pyrido[3,2-d]pyrimidin-2-amine
InChIKey: SZURKEABSBIIMJ-UHFFFAOYSA-N
SMILES: CC1=NC=C(C2=NC3=C(OC4(C)CC4)N=C(NC5=CN(C6CCN(C)CC6)N=C5)N=C3C=C2F)C=N1
Biological Activity: IRAK4-IN-14 (compound 28) is a potent, selective and orally active IRAK4 inhibitor with an IC50 of 0.003 µM. IRAK4-IN-14 shows good PK parameters in rats and mouse. IRAK4-IN-14 shows synergistic in vitro activity against MyD88/CD79 double mutant ABC-DLBCL in combination with Acalabrutinib[1].
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IRAK4-IN-14 | 99.01% | IRAK4-IN-14 (compound 28) is a potent, selective and orally active IRAK4 inhibitor with an IC50 of 0.003 µM. IRAK4-IN-14 shows good PK parameters in rats and mouse. IRAK4-IN-14 shows synergistic in vitro activity against MyD88/CD79 double mutant ABC-DLBCL in combination with Acalabrutinib. | ||||||||||||||||||||
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Keywords
