2684238-37-5
Chemical Structure
Autophagy inducer 2
- CAS No.: 2684238-37-5
- Formula:C41H58N6O
- Molecular Weight:650.94
IUPAC Name: N-((2R,4aS,6aS,6bS,16aS,16bR)-2,4a,6a,6b,9,16a-hexamethyl-1,2,3,4,4a,5,6,6a,6b,16,16a,16b-dodecahydrochryseno[1,2-g]quinoxalin-2-yl)-4-(1-methylpiperidin-4-yl)piperazine-1-carboxamide
InChIKey: KODKFUCFEMZRKX-JUIHQLMDSA-N
SMILES: C[C@]12[C@@]([C@]3(C(C4=CC5=NC=CN=C5C(C)=C4C=C3)=CC1)C)(CC[C@@]6([C@@]2([H])C[C@@](C)(CC6)NC(N7CCN(C8CCN(CC8)C)CC7)=O)C)C
Biological Activity: Autophagy inducer 2 (Compound 11i) is a potent autophagy inducer. Autophagy inducer 2 exhibits apparent antiproliferative activity against the MCF-7 cell line with an IC50 value of 1.31 μM and remarkably inhibits the colony formation of the MCF-7 cells. Autophagy inducer 2 arrests the MCF-7 cells in the G2/M phase by regulating the cell-cycle-related proteins Cdk-1 and Cyclin B1. Autophagy inducer 2 has the potential for the research of breast cancer[1].
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Autophagy inducer 2 | Autophagy inducer 2 (Compound 11i) is a potent autophagy inducer. Autophagy inducer 2 exhibits apparent antiproliferative activity against the MCF-7 cell line with an IC50 value of 1.31 μM and remarkably inhibits the colony formation of the MCF-7 cells. Autophagy inducer 2 arrests the MCF-7 cells in the G2/M phase by regulating the cell-cycle-related proteins Cdk-1 and Cyclin B1. Autophagy inducer 2 has the potential for the research of breast cancer. | |||||||||||||||||||||
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Keywords
