2699090-78-1
2699090-78-1
Chemical Structure
AChE-IN-7
- CAS No.: 2699090-78-1
- Formula:C26H28N2O2
- Molecular Weight:400.51
IUPAC Name: 5-(4-(2-methylpiperidin-1-yl)butoxy)-7H-dibenzo[de,h]quinolin-7-one
InChIKey: HVLZKNWEYCJMJK-UHFFFAOYSA-N
SMILES: O=C1C2=C(C3=NC=CC4=CC(OCCCCN5CCCCC5C)=CC1=C43)C=CC=C2
Biological Activity: AChE-IN-7 (Compound 16) is a selective and potent inhibitor of acetylcholinesterase (eeAChE IC50 = 0.045 μM; eeBuChE IC50 = 19.68 μM). AChE-IN-7 is safe in vivo and in vitro, and shows good overall pharmacokinetic performance and high bioavailability (F = 55.5%). AChE-IN-7 also has high BBB permeability[1].
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AChE-IN-7 | AChE-IN-7 (Compound 16) is a selective and potent inhibitor of acetylcholinesterase (eeAChE IC50 = 0.045 μM; eeBuChE IC50 = 19.68 μM). AChE-IN-7 is safe in vivo and in vitro, and shows good overall pharmacokinetic performance and high bioavailability (F = 55.5%). AChE-IN-7 also has high BBB permeability. | |||||||||||||||||||||
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Keywords
