2705841-17-2
Chemical Structure
Antitumor agent-196
- CAS No.: 2705841-17-2
- Formula:C51H81NO15
- Molecular Weight:948.19
SMILES: C[C@@H]1[C@@]2([H])[C@]34[C@@](O[C@@H]1OCCN(CCO[C@H]5O[C@@]6([H])[C@]78[C@](CC[C@H]([C@]7([H])CC[C@](O6)(OO8)C)C)([H])[C@H]5C)CCO[C@H]9O[C@@]%10([H])[C@]%11%12[C@](CC[C@H]([C@]%11([H])CC[C@](O%10)(OO%12)C)C)([H])[C@H]9C)([H])O[C@](OO3)(CC[C@@]4([H])[C@@H](CC2)C)C
Biological Activity: Antitumor agent-196 (Compound 6a (β, β, β)) is an artemisinin-based oligomer with anticancer activity, showing an IC50 of 90 nM against MCF-7 breast cancer cells. Antitumor agent-196 promotes Apoptosis by regulating the Bax-caspase 3 signaling pathway, and induces Ferroptosis through the modulation of key signaling molecules, including GPX4. Antitumor agent-196 holds promising potential for further research in the field of cancer therapy[1].
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Antitumor agent-196 | Antitumor agent-196 (Compound 6a (β, β, β)) is an artemisinin-based oligomer with anticancer activity, showing an IC50 of 90 nM against MCF-7 breast cancer cells. Antitumor agent-196 promotes Apoptosis by regulating the Bax-caspase 3 signaling pathway, and induces Ferroptosis through the modulation of key signaling molecules, including GPX4. Antitumor agent-196 holds promising potential for further research in the field of cancer therapy. | |||||||||||||||||||||
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Keywords
