2711039-08-4
Chemical Structure
ACSS2-IN-1
- CAS No.: 2711039-08-4
- Formula:C27H25ClN6O2
- Molecular Weight:500.98
IUPAC Name: 9,10-dimethoxy-3-(2-(methyl-d3)propyl-3,3,3-d3)-3,4,6,7-tetrahydro-2H-pyrido[2,1-a]isoquinolin-2-one
InChIKey: WLUNFHGEBAZYCQ-UHFFFAOYSA-N
SMILES: O=C(C1=CC2=C(CC)C(C(C3=CC=CC=C3)(C4=CC=CC=C4)O)=NN2C=C1Cl)NC5=NN(CC)C=N5
Biological Activity: ACSS2-IN-1 is a potent acetyl-CoA synthetase 2 (ACSS2) inhibitor with an IC50 of <1 nM. ACSS2-IN-1 inhibits ACSS2 enzymatic activity, blocks the metabolic pathway converting acetate to acetyl-CoA in cancer cells, and thereby suppresses tumor energy metabolism, lipid synthesis and histone acetylation. ACSS2-IN-1 can be used in the research of cancer and hyperproliferative disorders[1].
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ACSS2-IN-1 | ACSS2-IN-1 is a potent acetyl-CoA synthetase 2 (ACSS2) inhibitor with an IC50 of <1 nM. ACSS2-IN-1 inhibits ACSS2 enzymatic activity, blocks the metabolic pathway converting acetate to acetyl-CoA in cancer cells, and thereby suppresses tumor energy metabolism, lipid synthesis and histone acetylation. ACSS2-IN-1 can be used in the research of cancer and hyperproliferative disorders. | |||||||||||||||||||||
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