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Cat. No.: HY-145392

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ACSS2-IN-1

ACSS2-IN-1 is a potent acetyl-CoA synthetase 2 (ACSS2) inhibitor with an IC₅₀ of <1 nM. ACSS2-IN-1 inhibits ACSS2 enzymatic activity, blocks the metabolic pathway converting acetate to acetyl-CoA in cancer cells, and thereby suppresses tumor energy metabolism, lipid synthesis and histone acetylation. ACSS2-IN-1 can be used in the research of cancer and hyperproliferative disorders.

For research use only. We do not sell to patients.

CAS No.: 2711039-08-4
Formula: C₂₇H₂₅ClN₆O₂
Molecular Weight:500.98

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (280 KB)

ACSS2-IN-1 Chemical Structure

CAS No.: 2711039-08-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

^[1]

ACSS2

< 1 nM (IC₅₀)

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-15	IC50	<1 nM	Inhibition of ACSS2-mediated lipid synthesis in HCT-15 cancer cells. Inhibition of ACSS2-mediated lipid synthesis in HCT-15 cancer cells.	34917239

In Vitro

ACSS2-IN-1 (Compound 1) (2-4 h) inhibits endogenous fatty acid synthesis (IC₅₀ <1 nM) and endogenous histone acetylation (IC₅₀ <1 nM) in HCT-15 human colon cancer cells^[1].
ACSS2-IN-1 potently inhibits purified ACSS2 with an IC₅₀ of <1 nM^[1].
The product (0.2-100 μM; 24 h) shows no genotoxicity in CHO-K1 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2711039-08-4
Molecular Weight 500.98
Formula C₂₇H₂₅ClN₆O₂
SMILES

O=C(C1=CC2=C(CC)C(C(C3=CC=CC=C3)(C4=CC=CC=C4)O)=NN2C=C1Cl)NC5=NN(CC)C=N5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (280 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Sabnis RW. Amide-Substituted Condensed Pyridine Derivatives as ACSS2 Inhibitors for Treating Cancer. ACS Med Chem Lett. 2021 Nov 8;12(12):1870-1871. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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