2716185-86-1
Chemical Structure
CSF1R-IN-4
- CAS No.: 2716185-86-1
- Formula:C23H20N6O3
- Molecular Weight:428.44
IUPAC Name: 1-cyclopropyl-N-(5-((2-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yl)oxy)pyridin-2-yl)-2-oxo-1,2-dihydropyridine-3-carboxamide
InChIKey: SKXQHLVINGPJLX-UHFFFAOYSA-N
SMILES: O=C(C1=CC=CN(C2CC2)C1=O)NC3=NC=C(OC4=CC(C5=CN(C)N=C5)=NC=C4)C=C3
Biological Activity: CSF1R-IN-4 is a potent inhibitor of CSF1R. CSF-1R is expressed in macrophages, and the survival and differentiation of macrophages depends on the CSF-1/CSF-1R signaling pathway. CSF1R-IN-4 affects the exchange of inflammatory factors between TAMs and glioma cells. CSF1R-IN-4 has the potential for the research of cancer disease (extracted from patent WO2021197276A1, compound 104)[1].
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CSF1R-IN-4 | CSF1R-IN-4 is a potent inhibitor of CSF1R. CSF-1R is expressed in macrophages, and the survival and differentiation of macrophages depends on the CSF-1/CSF-1R signaling pathway. CSF1R-IN-4 affects the exchange of inflammatory factors between TAMs and glioma cells. CSF1R-IN-4 has the potential for the research of cancer disease (extracted from patent WO2021197276A1, compound 104). | |||||||||||||||||||||
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Keywords
