2739690-43-6
2739690-43-6
Chemical Structure
Luvometinib
Synonym(s): FCN-159
- CAS No.: 2739690-43-6
- Formula:C26H22F2IN5O4S
- Molecular Weight:665.45
InChIKey: RJFDJJABNSVLRB-UHFFFAOYSA-N
SMILES: O=C1C(F)=C(C2=C(N1C)C(C3=CC(NS(=O)(C4CC4)=O)=CC=C3)=NN(C5CC5)C2=O)NC6=CC=C(C=C6F)I
Biological Activity: Luvometinib is a mitogen-activated protein kinase (MEK) inhibitor with antitumor activity[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Luvometinib | 99.94% | Luvometinib is a mitogen-activated protein kinase (MEK) inhibitor with antitumor activity. | ||||||||||||||||||||
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Luvometinib-d | Luvometinib-d (FCN-159-d) is the deuterated-labeled Luvometinib (HY-159846). Luvometinib is an orally potent MEK1/2 inhibitor. Luvometinib selectively blocks the MAPK signaling pathway by forming a ternary complex with MEKase and ATP, thereby reducing the phosphorylation level of ERK. Luvometinib induces cell cycle arrest and apoptosis, and inhibits cancer cell proliferation. Luvometinib can be used in relevant research on various solid tumors including melanoma, non-small cell lung cancer, colon cancer, and acute myeloid leukemia. | |||||||||||||||||||||
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References
Keywords
