2739829-00-4
2739829-00-4
Chemical Structure
Zidesamtinib
Synonym(s): NVL-520; NUV-520
- CAS No.: 2739829-00-4
- Formula:C22H22FN7O
- Molecular Weight:419.45
InChIKey: DTWUUAFTYSMNQX-GFCCVEGCSA-N
SMILES: CCN1C2=C(C=N1)CC3=NN(C)N=C3C4=CC=C(F)C=C4[C@H](OC5=C(N)N=CC2=C5)C
Biological Activity: Zidesamtinib (NVL-520) is a potent, selective, orally active and brain-penetrant inhibitor of diverse ROS1 fusions and resistance mutations, with IC50s of 0.7 and 7.9 nM for wild-type ROS1 and ROS1 G2032R, respectively, and spares TRK inhibition. Zidesamtinib can be used for the research of cancer[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Zidesamtinib | 99.78% | Zidesamtinib (NVL-520) is a potent, selective, orally active and brain-penetrant inhibitor of diverse ROS1 fusions and resistance mutations, with IC50s of 0.7 and 7.9 nM for wild-type ROS1 and ROS1 G2032R, respectively, and spares TRK inhibition. Zidesamtinib can be used for the research of cancer. | ||||||||||||||||||||
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References
Keywords
