2752331-09-0
Chemical Structure
GSK040
- CAS No.: 2752331-09-0
- Formula:C29H34N4O4
- Molecular Weight:502.60
IUPAC Name: 1,5-dimethyl-N-((R)-2-(methylamino)-2-oxo-1-(tetrahydro-2H-pyran-4-yl)ethyl)-6-oxo-N-((S)-2-phenyl-2-(pyridin-2-yl)ethyl)-1,6-dihydropyridine-3-carboxamide
InChIKey: MDCZQITXTAMNNV-AOYPEHQESA-N
SMILES: O=C(C(C=C1C)=CN(C)C1=O)N([C@H](C2CCOCC2)C(NC)=O)C[C@H](C3=CC=CC=C3)C4=NC=CC=C4
Biological Activity: GSK040 is a potent and highly selective BET BD2 inhibitor, with a pIC50 of 8.3. GSK040 shows more than 5000-fold selectivity for BET BD2 over BET BD1 (pIC50=4.6). GSK040 can be used for the research of oncology and immunology diseases[1].
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GSK040 | GSK040 is a potent and highly selective BET BD2 inhibitor, with a pIC50 of 8.3. GSK040 shows more than 5000-fold selectivity for BET BD2 over BET BD1 (pIC50=4.6). GSK040 can be used for the research of oncology and immunology diseases. | |||||||||||||||||||||
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Keywords
