2755825-45-5
2755825-45-5
Chemical Structure
PARP1/NAMPT-IN-2
- CAS No.: 2755825-45-5
- Formula:C34H36FN7O3
- Molecular Weight:609.69
InChIKey: MJJYANKCWXTLBC-UHFFFAOYSA-N
SMILES: O=C(NCCCCCCN1CCN(C(C2=C(F)C=CC(CC3=NNC(C4=C3C=CC=C4)=O)=C2)=O)CC1)C5=CC6=NC=CN6C=C5
Biological Activity: PARP1/NAMPT-IN-2 (Compound 13j) is a dual PARP/NAMPT inhibitor with IC50 values of 0.8 nM and 18 nM for PARP1 and NAMPT, respectively. PARP1/NAMPT-IN-2 can inhibit the proliferation, migration and induce apoptosis of breast cancer cells. PARP1/NAMPT-IN-2 can be used for the research of triple-negative breast cancer[1].
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PARP1/NAMPT-IN-2 | PARP1/NAMPT-IN-2 (Compound 13j) is a dual PARP/NAMPT inhibitor with IC50 values of 0.8 nM and 18 nM for PARP1 and NAMPT, respectively. PARP1/NAMPT-IN-2 can inhibit the proliferation, migration and induce apoptosis of breast cancer cells. PARP1/NAMPT-IN-2 can be used for the research of triple-negative breast cancer. | |||||||||||||||||||||
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References
Keywords
