2758690-15-0
2758690-15-0
Chemical Structure
SOS1-IN-10
- CAS No.: 2758690-15-0
- Formula:C22H19F5N4O
- Molecular Weight:450.40
IUPAC Name: (R)-4-((1-(3-(difluoromethyl)-2-fluorophenyl)allyl)amino)-6-(1-(difluoromethyl)cyclopropyl)-2-methylpyrido[4,3-d]pyrimidin-7(6H)-one
InChIKey: UHHGMWHAPJSTJQ-OAHLLOKOSA-N
SMILES: C=C[C@H](C1=CC=CC(C(F)F)=C1F)NC2=NC(C)=NC3=CC(N(C=C32)C4(CC4)C(F)F)=O
Biological Activity: SOS1-IN-10 is a potent SOS1 inhibitor with an IC50 of 13 nM for KRAS G12C-SOS1 (WO2022017519A1, compound 8)[1].
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SOS1-IN-10 | SOS1-IN-10 is a potent SOS1 inhibitor with an IC50 of 13 nM for KRAS G12C-SOS1 (WO2022017519A1, compound 8). | |||||||||||||||||||||
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References
Keywords
