2758802-05-8
2758802-05-8
Chemical Structure
HSD17B13-IN-14
- CAS No.: 2758802-05-8
- Formula:C21H16ClN3O3S
- Molecular Weight:425.89
InChIKey: YGJDFURVOBVBAJ-UHFFFAOYSA-N
SMILES: O=C(C1=C(NC(C2=CC=C(O)C(Cl)=C2)=O)C=CS1)NCC3=CNC4=C3C=CC=C4
Biological Activity: HSD17B13-IN-14 (Compound 4) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC50 value of ≤ 1 μM for leukotriene B3 and ≤ 0.1 μM for estradiol. HSD17B13-IN-14 can be used in the research of liver diseases, metabolic disorders, or cardiovascular diseases such as NAFLD or NASH, or drug-induced liver injury (DILI)[1].
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HSD17B13-IN-14 | HSD17B13-IN-14 (Compound 4) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC50 value of ≤ 1 μM for leukotriene B3 and ≤ 0.1 μM for estradiol. HSD17B13-IN-14 can be used in the research of liver diseases, metabolic disorders, or cardiovascular diseases such as NAFLD or NASH, or drug-induced liver injury (DILI). | |||||||||||||||||||||
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References
Keywords
