2758802-19-4
Chemical Structure
HSD17B13-IN-23
- CAS No.: 2758802-19-4
- Formula:C18H20F2N2O3S
- Molecular Weight:382.42
InChIKey: UCHIHSPYCPELTB-UHFFFAOYSA-N
SMILES: O=C(NCCC(C)(C)C)C1=C(NC(C2=CC(F)=C(O)C(F)=C2)=O)C=CS1
Biological Activity: HSD17B13-IN-23 (compound 18) is a ppotent inhibitor of hydroxysteroid 17?-dehydrogenase 13 (HSD17B13), with the IC50 of < 0.1 μM and? < 1 μM estradiol and Leukotriene B3 as substrates, respectively. HSD17B13-IN-23? plays an important role in nonalcoholic fatty liver diseases (NAFLDs) including NASH (nonalcoholic steatohepatitis)[1].
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HSD17B13-IN-23 | HSD17B13-IN-23 (compound 18) is a ppotent inhibitor of hydroxysteroid 17?-dehydrogenase 13 (HSD17B13), with the IC50 of < 0.1 μM and? < 1 μM estradiol and Leukotriene B3 as substrates, respectively. HSD17B13-IN-23? plays an important role in nonalcoholic fatty liver diseases (NAFLDs) including NASH (nonalcoholic steatohepatitis). | |||||||||||||||||||||
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Keywords