2766190-68-3
2766190-68-3
Chemical Structure
MH44
- CAS No.: 2766190-68-3
- Formula:C20H23N7O6S
- Molecular Weight:489.50
InChIKey: ZHVNWPYRBLBLOS-WVSUBDOOSA-N
SMILES: O[C@H]1[C@@H](O)[C@H](N2C(N=CN=C3N)=C3N=C2)O[C@@H]1CN(S(=O)(C4=CC(C#N)=C(OC)C=C4)=O)CC
Biological Activity: MH44 is an efficient inhibitor targeting the SARS-CoV-2 nsp14 N7-methyltransferase (N7-MTase) with an IC50 of 19 nM. MH44 exhibits moderate antiviral effects in SARS-CoV-2-infected A549-hACE2 cells and shows certain cytotoxicity at higher concentrations. MH44 can be used in the research on anti-SARS-CoV-2[1].
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MH44 | MH44 is an efficient inhibitor targeting the SARS-CoV-2 nsp14 N7-methyltransferase (N7-MTase) with an IC50 of 19 nM. MH44 exhibits moderate antiviral effects in SARS-CoV-2-infected A549-hACE2 cells and shows certain cytotoxicity at higher concentrations. MH44 can be used in the research on anti-SARS-CoV-2. | |||||||||||||||||||||
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References
Keywords
