2771313-42-7
Chemical Structure
YL93
- CAS No.: 2771313-42-7
- Formula:C37H38Cl2F2N4O4
- Molecular Weight:711.62
IUPAC Name: 4-((2R,3S,4S,5S)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-5-neopentyl-4-(((pyridin-4-ylmethyl)amino)methyl)pyrrolidine-2-carboxamido)-3-methoxybenzoic acid
InChIKey: UBACXUKBTJKWLY-GXFZAZKKSA-N
SMILES: FC(C(Cl)=CC=C1)=C1[C@@H]([C@@H](N[C@H]2CC(C)(C)C)C(NC3=CC=C(C=C3OC)C(O)=O)=O)[C@]2(C4=CC=C(Cl)C=C4F)CNCC5=CC=NC=C5
Biological Activity: YL93 is a dual inhibitors of MDM2/4 with Ki values of 0.64 μM and 1.1 nM for MDM4 and MDM2, respectively. YL93 induces cell-cycle arrest and apoptosis. YL93 shows p53-dependent cell growth inhibition[1].
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YL93 | YL93 is a dual inhibitors of MDM2/4 with Ki values of 0.64 μM and 1.1 nM for MDM4 and MDM2, respectively. YL93 induces cell-cycle arrest and apoptosis. YL93 shows p53-dependent cell growth inhibition. | |||||||||||||||||||||
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Keywords
