2773925-64-5
Chemical Structure
Mu opioid receptor antagonist 2
- CAS No.: 2773925-64-5
- Formula:C25H28N2O4S
- Molecular Weight:452.57
IUPAC Name: N-((4R,4aS,7S,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-2,3,4,4a,5,6,7,7a-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl)thiophene-2-carboxamide
InChIKey: QWAXZSMUYRTIIN-SVWSUJCXSA-N
SMILES: O[C@]12[C@H]3CC4=C5[C@@]1(CCN3CC6CC6)[C@H]([C@H](CC2)NC(C7=CC=CS7)=O)OC5=C(O)C=C4
Biological Activity: Mu opioid receptor antagonist 2 (compound 25) is a potent, selective and blood-brain barrier (BBB) penetrant μ opioid receptor (MOR) antagonist with a Ki of 0.37 nM and an EC50 of 0.44 nM. Mu opioid receptor antagonist 2 has remarkable CNS antagonism against morphine, and precipitated fewer withdrawal symptoms than Naloxone. Mu opioid receptor antagonist 2 can be used for researching opioid use disorders (OUD)[1].
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Mu opioid receptor antagonist 2 | Mu opioid receptor antagonist 2 (compound 25) is a potent, selective and blood-brain barrier (BBB) penetrant μ opioid receptor (MOR) antagonist with a Ki of 0.37 nM and an EC50 of 0.44 nM. Mu opioid receptor antagonist 2 has remarkable CNS antagonism against morphine, and precipitated fewer withdrawal symptoms than Naloxone. Mu opioid receptor antagonist 2 can be used for researching opioid use disorders (OUD). | |||||||||||||||||||||
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Keywords
