2785430-88-6
Chemical Structure
ALK5-IN-32
- CAS No.: 2785430-88-6
- Formula:C23H23FN8
- Molecular Weight:430.48
IUPAC Name: 5-fluoro-N4-(8-methylcinnolin-4-yl)-N2-(4-(piperazin-1-yl)phenyl)pyrimidine-2,4-diamine
InChIKey: IJEFEOOYMCBEDC-UHFFFAOYSA-N
SMILES: CC1=CC=CC2=C(NC3=NC(NC4=CC=C(N5CCNCC5)C=C4)=NC=C3F)C=NN=C12
Biological Activity: ALK5-IN-32 (compound EX-09) is a selective ALK-5 inhibitor (10 nM<IC50<100 nM), inhibits TGF-β-induced SMAD signaling. ALK5-IN-32 has the potential to inhibit growth of tumour in vivo. ALK5-IN-32 can be used in study of proliferative diseases such as cancer, fibrotic diseases, and systemic sclerosis[1].
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ALK5-IN-32 | ALK5-IN-32 (compound EX-09) is a selective ALK-5 inhibitor (10 nM<IC50<100 nM), inhibits TGF-β-induced SMAD signaling. ALK5-IN-32 has the potential to inhibit growth of tumour in vivo. ALK5-IN-32 can be used in study of proliferative diseases such as cancer, fibrotic diseases, and systemic sclerosis. | |||||||||||||||||||||
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Keywords
