280118-23-2
280118-23-2
Chemical Structure
BMS-740808
- CAS No.: 280118-23-2
- Formula:C31H27F3N6O3
- Molecular Weight:588.58
IUPAC Name: (R)-1-(3-aminobenzo[d]isoxazol-5-yl)-6-(2'-((3-hydroxypyrrolidin-1-yl)methyl)-[1,1'-biphenyl]-4-yl)-3-(trifluoromethyl)-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one
InChIKey: DFRIQJHMGZBFOM-JOCHJYFZSA-N
SMILES: O=C1C2=C(CCN1C3=CC=C(C4=C(C=CC=C4)CN5CC[C@H](C5)O)C=C3)C(C(F)(F)F)=NN2C6=CC=C(ON=C7N)C7=C6
Biological Activity: BMS-740808 is a potent, selective and orally active factor Xa inhibitor with a Ki of 30 pM. BMS-740808 shows >1000-fold for factor Xa than other proteases[1].
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BMS-740808 | BMS-740808 is a potent, selective and orally active factor Xa inhibitor with a Ki of 30 pM. BMS-740808 shows >1000-fold for factor Xa than other proteases. | |||||||||||||||||||||
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References
- [1]. Donald J P Pinto, et al. 1-[3-Aminobenzisoxazol-5'-yl]-3-trifluoromethyl-6-[2'-(3-(R)-hydroxy-N-pyrrolidinyl)methyl-[1,1']-biphen-4-yl]-1,4,5,6-tetrahydropyrazolo-[3,4-c]-pyridin-7-one (BMS-740808) a highly potent, selective, efficacious, and orally bioavailable inhibitor of blood coagulation factor Xa. Bioorg Med Chem Lett. 2006 Aug 1;16(15):4141-7. [Content Brief]
Keywords
