2835559-00-5
Chemical Structure
Tubulin polymerization-IN-4
- CAS No.: 2835559-00-5
- Formula:C21H21ClN2O4
- Molecular Weight:400.86
IUPAC Name: 5-(3-chloro-4-ethoxyphenyl)-4-(3,4,5-trimethoxyphenyl)pyrimidine
InChIKey: PMXUZPJQMLRIPX-UHFFFAOYSA-N
SMILES: CCOC1=CC=C(C=C1Cl)C2=C(N=CN=C2)C3=CC(OC)=C(C(OC)=C3)OC
Biological Activity: Tubulin polymerization-IN-4 is a potent tubulin polymerization inhibitor with IC50 value of 4.6 μM. Tubulin polymerization-IN-4 can disrupt tubulin polymerization and vasculature, arrest the cell cycle at the G2/M phase, induce apoptosis, and suppress clonogenesis and migration in HeLa cells. Tubulin polymerization-IN-4 can be used for researching cervical cancer[1].
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Tubulin polymerization-IN-4 | Tubulin polymerization-IN-4 is a potent tubulin polymerization inhibitor with IC50 value of 4.6 μM. Tubulin polymerization-IN-4 can disrupt tubulin polymerization and vasculature, arrest the cell cycle at the G2/M phase, induce apoptosis, and suppress clonogenesis and migration in HeLa cells. Tubulin polymerization-IN-4 can be used for researching cervical cancer. | |||||||||||||||||||||
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Keywords
