2847881-81-4
2847881-81-4
Chemical Structure
TH-Z827
- CAS No.: 2847881-81-4
- Formula:C30H38N6O
- Molecular Weight:498.66
InChIKey: PDTKGMUEAPACDB-VXNXHJTFSA-N
SMILES: CN(CCC1)[C@@H]1COC2=NC(N3[C@@H]4CNC[C@H]3CC4)=C5C(CN(C6=CC=CC7=C6C(C)=CC=C7)CC5)=N2
Biological Activity: TH-Z827 is a selective KRASG12D inhibitor that exhibits activity against GDP-bound and GMPPNP-bound KRASG12D, but shows no activity against KRAS (WT) and KRASG12C. TH-Z827 blocks the KRASG12D-CRAF interaction with a IC50 value of 42 μM. TH-Z827 can be used for the research of pancreatic cancer[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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TH-Z827 | 95.12% | TH-Z827 is a selective KRASG12D inhibitor that exhibits activity against GDP-bound and GMPPNP-bound KRASG12D, but shows no activity against KRAS (WT) and KRASG12C. TH-Z827 blocks the KRASG12D-CRAF interaction with a IC50 value of 42 μM. TH-Z827 can be used for the research of pancreatic cancer. | ||||||||||||||||||||
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