2847881-81-4

TH-Z827 Chemical Structure
2847881-81-4

Chemical Structure

TH-Z827

  • CAS No.: 2847881-81-4
  • Formula:C30H38N6O
  • Molecular Weight:498.66

InChIKey: PDTKGMUEAPACDB-VXNXHJTFSA-N

SMILES: CN(CCC1)[C@@H]1COC2=NC(N3[C@@H]4CNC[C@H]3CC4)=C5C(CN(C6=CC=CC7=C6C(C)=CC=C7)CC5)=N2

Biological Activity: TH-Z827 is a mutant selective KRAS(G12D) inhibitor with an IC50 of 2.4 μM. TH-Z827 does not bind KRAS(WT) or KRAS(G12C). TH-Z827 blocked the KRAS(G12D)-CRAF interaction with an IC50 value of 42 μM[1].

Cat. No. Product Name Purity Description Pricing
HY-153663 		TH-Z827 95.12% TH-Z827 is a mutant selective KRAS(G12D) inhibitor with an IC50 of 2.4 μM. TH-Z827 does not bind KRAS(WT) or KRAS(G12C). TH-Z827 blocked the KRAS(G12D)-CRAF interaction with an IC50 value of 42 μM.
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