2882851-77-4
Chemical Structure
EGFR-IN-48
- CAS No.: 2882851-77-4
- Formula:C35H47BrN9O4PS
- Molecular Weight:800.75
IUPAC Name: (6-((5-bromo-2-((5-ethyl-2-methoxy-4-(4-(4-(2-(methylsulfonyl)ethyl)piperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)quinoxalin-5-yl)dimethylphosphine oxide
InChIKey: VFCRMLIPZXPGDA-UHFFFAOYSA-N
SMILES: CCC1=CC(NC2=NC=C(C(NC3=CC=C4N=CC=NC4=C3P(C)(C)=O)=N2)Br)=C(C=C1N5CCC(CC5)N6CCN(CC6)CCS(C)(=O)=O)OC
Biological Activity: EGFR-IN-48 is a potent and orally active EGFR inhibitor with IC50s of 0.193 nM, 0.251 nM, 10.4 nM for EGFRd19/TM/CS, EGFRLR/TM/CS, EGFRWT, respectively. EGFR-IN-48 inhibits the proliferation of BaF3EGFR del19/T790M/C797S and PC-9EGFR del19/T790M/C797S cells with IC50s of 1.526, 66.7 nM, respectively[1].
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EGFR-IN-48 | EGFR-IN-48 is a potent and orally active EGFR inhibitor with IC50s of 0.193 nM, 0.251 nM, 10.4 nM for EGFRd19/TM/CS, EGFRLR/TM/CS, EGFRWT, respectively. EGFR-IN-48 inhibits the proliferation of BaF3EGFR del19/T790M/C797S and PC-9EGFR del19/T790M/C797S cells with IC50s of 1.526, 66.7 nM, respectively. | |||||||||||||||||||||
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Keywords
