2896737-31-6
Chemical Structure
SAH-SOS1A TFA
- CAS No.: 2896737-31-6
- Formula:C102H160N27F3O30
- Molecular Weight:2301.55
InChIKey: VNWKTOKETHGBQD-UHFFFAOYSA-N
SMILES: C[C@]1(C(N[C@H](C(N[C@@](C(N[C@H](C(N[C@@](C)(CCC/C=C/CCC1)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(NCC(N[C@H](C(O)=O)CC(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC(N)=O)=O)([H])[C@H](O)C)=O)CC(C)C)=O)NC([C@H]([C@@H](C)CC)NC(CNC([C@H](CC2=CC=CC=C2)NC([C@@H](NC([C@H](CCCNC(N)=N)NC([C@@H](NC(C)=O)CCCNC(N)=N)=O)=O)CC3=CC=CC=C3)=O)=O)=O)=O.OC(C(F)(F)F)=O
Biological Activity: SAH-SOS1A TFA is a peptide-based SOS1/KRAS protein interaction inhibitor. SAH-SOS1A TFA binds to wild-type and mutant KRAS (G12D, G12V, G12C, G12S, and Q61H) with nanomolar affinity (EC50=106-175 nM). SAH-SOS1A TFA directly and independently blocks nucleotide association. SAH-SOS1A TFA impairs KRAS-driven cancer cell viability and exerts its effects by on-mechanism blockade of the ERK-MAPK phosphosignaling cascade downstream of KRAS[1].
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SAH-SOS1A TFA | 96.55% | SAH-SOS1A TFA is a peptide-based SOS1/KRAS protein interaction inhibitor. SAH-SOS1A TFA binds to wild-type and mutant KRAS (G12D, G12V, G12C, G12S, and Q61H) with nanomolar affinity (EC50=106-175 nM). SAH-SOS1A TFA directly and independently blocks nucleotide association. SAH-SOS1A TFA impairs KRAS-driven cancer cell viability and exerts its effects by on-mechanism blockade of the ERK-MAPK phosphosignaling cascade downstream of KRAS. | ||||||||||||||||||||
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Keywords
