2911646-14-3

A09-003 Chemical Structure
2911646-14-3

Chemical Structure

A09-003

  • CAS No.: 2911646-14-3
  • Formula:C23H26N4O
  • Molecular Weight:374.48

InChIKey: VPUDUHFHZJGMMU-UHFFFAOYSA-N

SMILES: COC1=CC=CC=C1C2=CC=NC(NC3=CC=CC(N4CCCNCC4)=C3)=C2

Biological Activity: A09-003 is a CDK-9 inhibitor (IC50: 16 nM). A09-003 inhibits leukemia cell proliferation (IC50: 1.90, 0.86, 2.49, 1.84, 0.48 μM for BDCM, Molm-14, THP-1, U937, MV4-11 cells). A09-003 induces apoptosis and decreases Mcl-1 expression through Thr163 dephosphorylation[1].

Cat. No. Product Name Purity Description Pricing
HY-155245 		A09-003 A09-003 is a CDK-9 inhibitor (IC50: 16 nM). A09-003 inhibits leukemia cell proliferation (IC50: 1.90, 0.86, 2.49, 1.84, 0.48 μM for BDCM, Molm-14, THP-1, U937, MV4-11 cells). A09-003 induces apoptosis and decreases Mcl-1 expression through Thr163 dephosphorylation.
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