2. Cell Cycle/DNA Damage Apoptosis
  3. CDK Bcl-2 Family
  4. A09-003

A09-003 is a CDK-9 inhibitor (IC50: 16 nM). A09-003 inhibits leukemia cell proliferation (IC50: 1.90, 0.86, 2.49, 1.84, 0.48 μM for BDCM, Molm-14, THP-1, U937, MV4-11 cells). A09-003 induces apoptosis and decreases Mcl-1 expression through Thr163 dephosphorylation.

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A09-003 Chemical Structure

A09-003 Chemical Structure

CAS No. : 2911646-14-3

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A09-003 Related Antibodies

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Description

A09-003 is a CDK-9 inhibitor (IC50: 16 nM). A09-003 inhibits leukemia cell proliferation (IC50: 1.90, 0.86, 2.49, 1.84, 0.48 μM for BDCM, Molm-14, THP-1, U937, MV4-11 cells). A09-003 induces apoptosis and decreases Mcl-1 expression through Thr163 dephosphorylation[1].

IC50 & Target

Mcl-1

 

Molecular Weight

374.48

Formula

C23H26N4O
CAS No.
SMILES

COC1=CC=CC=C1C2=CC=NC(NC3=CC=CC(N4CCCNCC4)=C3)=C2
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Purity & Documentation
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A09-003 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

A09-0032911646-14-3CDKBcl-2 FamilyCyclin dependent kinaseMV4-11Molm-14AMLleukemiaMcl-1BDCMTHP-1U937Inhibitorinhibitorinhibit

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