2918334-61-7
2918334-61-7
Chemical Structure
MsbA-IN-1
- CAS No.: 2918334-61-7
- Formula:C23H18Cl2FNO3
- Molecular Weight:446.30
IUPAC Name: (S,E)-3-(4-cyclopropyl-6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)quinolin-3-yl)acrylic acid
InChIKey: YAPUPOWTSZLIAO-KFRNIWOLSA-N
SMILES: O=C(O)/C=C/C1=C(C2CC2)C3=CC(O[C@H](C4=C(Cl)C=CC(F)=C4Cl)C)=CC=C3N=C1
Biological Activity: MsbA-IN-1 is a highly potent MsbA inhibitor with IC50 of 4 nM. MsbA-IN-1 has activity against wild-type E. coli with MIC of 79 μM. MsbA-IN-1 possesses sufficient permeability across the fully intact outer membrane of Gram-negative bacteria to inhibit MsbA[1].
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MsbA-IN-1 | MsbA-IN-1 is a highly potent MsbA inhibitor with IC50 of 4 nM. MsbA-IN-1 has activity against wild-type E. coli with MIC of 79 μM. MsbA-IN-1 possesses sufficient permeability across the fully intact outer membrane of Gram-negative bacteria to inhibit MsbA. | |||||||||||||||||||||
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References
Keywords
