2929304-61-8
Chemical Structure
UNC8153 TFA
- CAS No.: 2929304-61-8
- Formula:C35H38F3N5O7
- Molecular Weight:697.70
InChIKey: PRNFABQCXAELBV-UHFFFAOYSA-N
SMILES: O=C(C(F)(F)F)O.O=C(C1=CC=C(CN(C2CC2)C(C3=CC=C4NC(COC4=C3)=O)=O)C=C1)NC5=CC=C(C(NCCCCCCN)=O)C=C5
Biological Activity: UNC8153 TFA is a potent and selective nuclear receptor-binding SET domain-containing 2 (NSD2)-targeted degrader with a Kd of 24 nM. UNC8153 TFA reduces the cellular levels of both NSD2 protein (DC50 in cell U2OS is 0.35 μM) and the H3K36me2 chromatin mark. UNC8153 TFA contains a simple warhead that confers proteasome-dependent degradation of NSD2[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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UNC8153 TFA | 99.92% | UNC8153 TFA is a potent and selective nuclear receptor-binding SET domain-containing 2 (NSD2)-targeted degrader with a Kd of 24 nM. UNC8153 TFA reduces the cellular levels of both NSD2 protein (DC50 in cell U2OS is 0.35 μM) and the H3K36me2 chromatin mark. UNC8153 TFA contains a simple warhead that confers proteasome-dependent degradation of NSD2. | ||||||||||||||||||||
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Keywords
