2968419-65-8
2968419-65-8
Chemical Structure
EGFR-IN-81
- CAS No.: 2968419-65-8
- Formula:C28H24F3N5O4
- Molecular Weight:551.52
InChIKey: WTZZJDHKIGPDFO-UHFFFAOYSA-N
SMILES: FC(F)(F)C1=CC=C(NC(C2=CC=C(N(CCC3=CC=C(O)C=C3)C(NC4C(NC(CC4)=O)=O)=N5)C5=C2)=O)C=C1
Biological Activity: EGFR-IN-81 (Compound 10i) is an EGFR inhibitor. EGFR-IN-81 inhibits EGFR WT and L858R/T790M with IC50s 4.38 nM and 5.69 nM. EGFR-IN-81 has cytotoxic activity against MCF-7 and HCT116 cells with of 2.07 μM and 6.72 μM respectively[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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EGFR-IN-81 | EGFR-IN-81 (Compound 10i) is an EGFR inhibitor. EGFR-IN-81 inhibits EGFR WT and L858R/T790M with IC50s 4.38 nM and 5.69 nM. EGFR-IN-81 has cytotoxic activity against MCF-7 and HCT116 cells with of 2.07 μM and 6.72 μM respectively. | |||||||||||||||||||||
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References
Keywords
