2975257-92-0
Chemical Structure
(R,R,R)-AHPC
- CAS No.: 2975257-92-0
- Formula:C22H30N4O3S
- Molecular Weight:430.56
InChIKey: ZLOXMSNKPDWMEF-LMMKCTJWSA-N
SMILES: O=C([C@@H]1N(C([C@@H](C(C)(C)C)N)=O)C[C@H](O)C1)NCC2=CC=C(C3=C(C)N=CS3)C=C2
Biological Activity: (R,R,R)-AHPC is an E3 ubiquitin ligase ligand and serves as one of the E3 ligands for R4VPL3-1 (HY-184506). R4VPL3-1 is a molecular glue targeting RNF4 and VHL, which binds to and modifies GPX4 to inhibit its anti-ferroptosis function. R4VPL3-1 induces iron-dependent lipid peroxidation and ferroptosis-mediated rapid cell death in cancer cells. R4VPL3-1 can be used for cancer-related research[1].
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(R,R,R)-AHPC | (R,R,R)-AHPC is an E3 ubiquitin ligase ligand and serves as one of the E3 ligands for R4VPL3-1 (HY-184506). R4VPL3-1 is a molecular glue targeting RNF4 and VHL, which binds to and modifies GPX4 to inhibit its anti-ferroptosis function. R4VPL3-1 induces iron-dependent lipid peroxidation and ferroptosis-mediated rapid cell death in cancer cells. R4VPL3-1 can be used for cancer-related research. | |||||||||||||||||||||
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Keywords
