(R,R,R)-AHPC
(R,R,R)-AHPC is an E3 ubiquitin ligase ligand and serves as one of the E3 ligands for R4VPL3-1 (HY-184506). R4VPL3-1 is a molecular glue targeting RNF4 and VHL, which binds to and modifies GPX4 to inhibit its anti-ferroptosis function. R4VPL3-1 induces iron-dependent lipid peroxidation and ferroptosis-mediated rapid cell death in cancer cells. R4VPL3-1 can be used for cancer-related research.
For research use only. We do not sell to patients.
- CAS No.: 2975257-92-0
- Formula: C22H30N4O3S
- Molecular Weight:430.56
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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VHL |
(R,R,R)-AHPC is one of the E3 ligands of R4VPL3-1 (HY-184506). R4VPL3-1 is a molecular glue targeting RNF4 and VHL, which binds to and modifies GPX4 to inhibit its anti-ferroptosis function. R4VPL3-1 induces iron-dependent lipid peroxidation and ferroptosis-mediated rapid cell death in cancer cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2975257-92-0
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Molecular Weight 430.56
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Formula C22H30N4O3S
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SMILES
O=C([C@@H]1N(C([C@@H](C(C)(C)C)N)=O)C[C@H](O)C1)NCC2=CC=C(C3=C(C)N=CS3)C=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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