(R,R,R)-AHPC
(R,R,R)-AHPC is an E3 ubiquitin ligase ligand and serves as one of the E3 ligands for R4VPL3-1 (HY-184506). R4VPL3-1 is a molecular glue targeting RNF4 and VHL, which binds to and modifies GPX4 to inhibit its anti-ferroptosis function. R4VPL3-1 induces iron-dependent lipid peroxidation and ferroptosis-mediated rapid cell death in cancer cells. R4VPL3-1 can be used for cancer-related research.
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- No. CAS: 2975257-92-0
- Fòrmula: C22H30N4O3S
- Peso molecular:430.56
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
IC50 & Target
[1]|
VHL |
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 2975257-92-0
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Peso molecular 430.56
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Fòrmula C22H30N4O3S
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SMILES
O=C([C@@H]1N(C([C@@H](C(C)(C)C)N)=O)C[C@H](O)C1)NCC2=CC=C(C3=C(C)N=CS3)C=C2
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(R,R,R)-AHPC Related Classifications
HY-184507 Related Classifications
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Keywords
- (R,R,R)-AHPC
- 2975257-92-0
- Ligands for E3 Ligase
- E3 ligase-recruiting Moiety
- primary mouse embryonic fibroblasts
- RTKi-resistant melanoma
- B16F10 mouse melanoma cells
- squamous skin cancer
- iron chelators
- VHL
- cancer cells
- ferroptosis inhibitors
- Von Hippel-Lindau protein
- ferroptotic cell death
- Inhibitor
- inhibitor
- inhibit