(R,R,R)-AHPC
(R,R,R)-AHPC is an E3 ubiquitin ligase ligand and serves as one of the E3 ligands for R4VPL3-1 (HY-184506). R4VPL3-1 is a molecular glue targeting RNF4 and VHL, which binds to and modifies GPX4 to inhibit its anti-ferroptosis function. R4VPL3-1 induces iron-dependent lipid peroxidation and ferroptosis-mediated rapid cell death in cancer cells. R4VPL3-1 can be used for cancer-related research.
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- CAS No.: 2975257-92-0
- Formule: C22H30N4O3S
- Masse moléculaire:430.56
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
VHL |
In Vitro
(R,R,R)-AHPC is one of the E3 ligands of R4VPL3-1 (HY-184506). R4VPL3-1 is a molecular glue targeting RNF4 and VHL, which binds to and modifies GPX4 to inhibit its anti-ferroptosis function. R4VPL3-1 induces iron-dependent lipid peroxidation and ferroptosis-mediated rapid cell death in cancer cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2975257-92-0
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Masse moléculaire 430.56
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Formule C22H30N4O3S
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SMILES
O=C([C@@H]1N(C([C@@H](C(C)(C)C)N)=O)C[C@H](O)C1)NCC2=CC=C(C3=C(C)N=CS3)C=C2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(R,R,R)-AHPC Related Classifications
HY-184507 Related Classifications
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