2978670-53-8
Chemical Structure
Antitumor agent-210
- CAS No.: 2978670-53-8
- Formula:C28H30ClNO8
- Molecular Weight:544.00
IUPAC Name: (S)-2-((S)-5-chloro-6a-methyl-9-((E)-2-methylbut-2-enoyl)-3-((S,E)-3-methylpent-1-en-1-yl)-6,8-dioxo-6a,8-dihydrofuro[2,3-h]isoquinolin-2(6H)-yl)pentanedioic acid
InChIKey: VGRUPZJJCLCFOM-IISFDLNQSA-N
SMILES: C[C@]12C(C=3C(C=C(/C=C/[C@H](CC)C)N([C@@H](CCC(O)=O)C(O)=O)C3)=C(Cl)C1=O)=C(C(/C(=C/C)/C)=O)C(=O)O2
Biological Activity: Antitumor agent-210 (Compound 1778) is an NK cell activator. Antitumor agent-210 has a weak proliferative effect on NK92 cells, promoting the activation and degranulation of NK cells, and significantly enhancing the cytotoxicity of NK92 cells against tumor cells. Antitumor agent-210 promotes the release of cytokine granzyme B, perforin, and IFN-γ. Antitumor agent-210 reduces the number of lung metastatic lesions in mice and can be used for the study of melanoma lung metastasis[1].
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Antitumor agent-210 | Antitumor agent-210 (Compound 1778) is an NK cell activator. Antitumor agent-210 has a weak proliferative effect on NK92 cells, promoting the activation and degranulation of NK cells, and significantly enhancing the cytotoxicity of NK92 cells against tumor cells. Antitumor agent-210 promotes the release of cytokine granzyme B, perforin, and IFN-γ. Antitumor agent-210 reduces the number of lung metastatic lesions in mice and can be used for the study of melanoma lung metastasis. | |||||||||||||||||||||
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Keywords
