2982893-14-9
Chemical Structure
Tubulin polymerization-IN-84
- CAS No.: 2982893-14-9
- Formula:C23H22N2O3
- Molecular Weight:374.43
InChIKey: MQOVOQHTDHUQBA-UHFFFAOYSA-N
SMILES: COC1=CC(C2=CC=CN3C=C(N=C23)C4=CC=C(C=C4)C)=CC(OC)=C1OC
Biological Activity: Tubulin polymerization-IN-84 inhibits tubulin polymerization by targeting the colchicine-binding pocket, with anIC50 = 10.9 μM. Tubulin polymerization-IN-84 shows antiproliferative activity against Jurkat, B16-F10, HCT116, and MDA-MB-231 cells (IC50 = 60 nM, 380 nM, 138 nM, and 1.054 μM). Tubulin polymerization-IN-84 induces G2/M-phase arrest and apoptosis in B16-F10 cells. Tubulin polymerization-IN-84 suppresses tumor growth in a B16-F10 melanoma model and potentiates anti-tumor immunity in combination with a PD-L1 mAb for the research of T-cell acute lymphoblastic leukemia, melanoma, colon cancer, and breast cancer.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Tubulin polymerization-IN-84 | 99.59% | Tubulin polymerization-IN-84 inhibits tubulin polymerization by targeting the colchicine-binding pocket, with anIC50 = 10.9 μM. Tubulin polymerization-IN-84 shows antiproliferative activity against Jurkat, B16-F10, HCT116, and MDA-MB-231 cells (IC50 = 60 nM, 380 nM, 138 nM, and 1.054 μM). Tubulin polymerization-IN-84 induces G2/M-phase arrest and apoptosis in B16-F10 cells. Tubulin polymerization-IN-84 suppresses tumor growth in a B16-F10 melanoma model and potentiates anti-tumor immunity in combination with a PD-L1 mAb for the research of T-cell acute lymphoblastic leukemia, melanoma, colon cancer, and breast cancer. | ||||||||||||||||||||
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Keywords
