3024881-00-0
Chemical Structure
Eras-4001-d6
- CAS No.: 3024881-00-0
- Formula:C36H33D6ClF4N8O3
- Molecular Weight:749.24
IUPAC Name: 5-((S)-7-(3-amino-2-fluoro-5-(prop-1-yn-1-yl)-6-(trifluoromethyl)phenyl)-2-(((S)-2-methylenetetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-4-yl)-3-chloro-N,N-bis(methyl-d3)-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a][1,4]diazepine-2-carboxamide
InChIKey: MQIGGDZYPCCUDF-NQINVOJISA-N
SMILES: C(OC1=NC(=C2C(=N1)C[C@H](OC2)C3=C(C(F)(F)F)C(C#CC)=CC(N)=C3F)N4CC=5N(CCC4)N=C(C(N(C([2H])([2H])[2H])C([2H])([2H])[2H])=O)C5Cl)[C@@]67N(CC(=C)C6)CCC7
Biological Activity: Eras-4001-d6 is a deuterated form of Eras-4001 (HY-175870). Eras-4001 is a potent, orally active pan-KRAS inhibitor with Kd values of 110, 13 and 39 pM against wild-type, G12D and G12V mutant KRAS, respectively, and exhibits selectivity toward wild-type HRAS and NRAS. Eras-4001 inhibits ERK1/2 phosphorylation and cell viability in cancer cells. Eras-4001 induces tumor growth inhibition and regression in subcutaneous xenograft models. Eras-4001 can be used in research on non-small cell lung cancer, ovarian cancer, etc.[1]
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Eras-4001-d6 | Eras-4001-d6 is a deuterated form of Eras-4001 (HY-175870). Eras-4001 is a potent, orally active pan-KRAS inhibitor with Kd values of 110, 13 and 39 pM against wild-type, G12D and G12V mutant KRAS, respectively, and exhibits selectivity toward wild-type HRAS and NRAS. Eras-4001 inhibits ERK1/2 phosphorylation and cell viability in cancer cells. Eras-4001 induces tumor growth inhibition and regression in subcutaneous xenograft models. Eras-4001 can be used in research on non-small cell lung cancer, ovarian cancer, etc. | |||||||||||||||||||||
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