3026500-20-6
3026500-20-6
Chemical Structure
VVD-214
Synonym(s): RO7589831; VVD-133214
- CAS No.: 3026500-20-6
- Formula:C20H21F2N3O4S
- Molecular Weight:437.46
InChIKey: UWPFUBNCDABUEE-SIFUEBAJSA-N
SMILES: CS(/C=C/[C@H](C1CC1)NC(C(C(OC2=CC=CC=C2)=N3)=CN=C3C(F)(F)C)=O)(=O)=O
Biological Activity: VVD-214 is a synthetic lethal allosteric inhibitor of WRN helicase with an IC50 of 0.1316 µM. VVD-214 covalently binds to cysteine 727 of WRN and inhibits ATP hydrolysis and helicase activity. VVD-214 is potent in causing double-stranded DNA breaks, nuclear swelling, and cell death in high microsatellite instability (MSI) cancers[1][2].
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VVD-214 | 99.99% | VVD-214 is a synthetic lethal allosteric inhibitor of WRN helicase with an IC50 of 0.1316 µM. VVD-214 covalently binds to cysteine 727 of WRN and inhibits ATP hydrolysis and helicase activity. VVD-214 is potent in causing double-stranded DNA breaks, nuclear swelling, and cell death in high microsatellite instability (MSI) cancers. | ||||||||||||||||||||
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References
Keywords
