3030493-05-8
3030493-05-8
Chemical Structure
RP03707
- CAS No.: 3030493-05-8
- Formula:C55H58F3N11O4
- Molecular Weight:994.12
InChIKey: PLUHAAKDSAEFSC-AQOUDTPCSA-N
SMILES: O=C1NC(CCN1C2=NN(C)C3=C2C=C(F)C(C4CCN(C5CC6(CCN(CC7(COC8=NC9=C(C=NC(C%10=C%11C(C#C)=C(F)C=CC%11=CC(O)=C%10)=C9F)C(N%12C[C@H]%13N[C@H](CC%13)C%12)=N8)CC7)CC6)C5)CC4)=C3)=O
Biological Activity: RP03707 is a PROTAC degrader of KRASG12D. RP03707 forms a ternary complex with KRASG12D and the CRBN E3 ligase, promoting the ubiquitination and proteasomal degradation of KRASG12D. RP03707 inhibits the growth of KRASG12D-positive tumor cells[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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RP03707 | 98.00% | RP03707 is a PROTAC degrader of KRASG12D. RP03707 forms a ternary complex with KRASG12D and the CRBN E3 ligase, promoting the ubiquitination and proteasomal degradation of KRASG12D. RP03707 inhibits the growth of KRASG12D-positive tumor cells. | ||||||||||||||||||||
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References
Keywords
