3031784-60-5
Chemical Structure
G4/HDAC-IN-1
- CAS No.: 3031784-60-5
- Formula:C36H49ClFN7O4
- Molecular Weight:698.27
IUPAC Name: (E)-N-(3-(dimethylamino)propyl)-4-((7-fluoro-6-(4-(8-(hydroxyamino)-8-oxooctyl)piperazin-1-yl)-9-oxo-1,2-dihydropyrrolo[2,1-b]quinazolin-3(9H)-ylidene)methyl)benzamide hydrochloride
InChIKey: LVHIQYGIJSRTAN-XVBNZNTOSA-N
SMILES: O=C(NCCCN(C)C)C1=CC=C(/C=C2CCN3C\2=NC4=C(C=C(F)C(N5CCN(CCCCCCCC(NO)=O)CC5)=C4)C3=O)C=C1.Cl
Biological Activity: G4/HDAC-IN-1 (compound a6) is a G4/HDAC dual-targeting compound. G4/HDAC-IN-1 inhibits intracellular HDAC activity with an IC50 value of 1.1 μM, and induces G4 formation. G4/HDAC-IN-1 inhibits TNBC proliferation and tumor growth in TNBC xenograft model. G4/HDAC-IN-1 can be used for the research of cancer[1].
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G4/HDAC-IN-1 | G4/HDAC-IN-1 (compound a6) is a G4/HDAC dual-targeting compound. G4/HDAC-IN-1 inhibits intracellular HDAC activity with an IC50 value of 1.1 μM, and induces G4 formation. G4/HDAC-IN-1 inhibits TNBC proliferation and tumor growth in TNBC xenograft model. G4/HDAC-IN-1 can be used for the research of cancer. | |||||||||||||||||||||
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Keywords
