3032314-99-8
Chemical Structure
XYD113
- CAS. Nr.: 3032314-99-8
- Formula:C21H21ClN4O4
- Molecular Weight:428.87
InChIKey: URCPONFUJISESJ-UHFFFAOYSA-N
SMILES: ClC1=CC(NC(NCC2=CC=CC(C(NC3CCC(NC3=O)=O)=O)=C2)=O)=CC=C1C
Biological Activity: XYD113 is an orally active, selective GSPT1 Molecular glue degrader. XYD113 promotes the formation of the CRBN-GSPT1 ternary complex and mediates GSPT1 degradation in a CRBN-dependent manner via the ubiquitin-proteasome system. XYD113 downregulates genes associated with the occurrence and progression of prostate cancer (c-Myc, AR, AR-V7, KLK3, KLK2, TMPRSS2). XYD113 exhibits anticancer activity against prostate cancer. XYD113 can be used in the research of prostate cancer[1].
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XYD113 | XYD113 is an orally active, selective GSPT1 Molecular glue degrader. XYD113 promotes the formation of the CRBN-GSPT1 ternary complex and mediates GSPT1 degradation in a CRBN-dependent manner via the ubiquitin-proteasome system. XYD113 downregulates genes associated with the occurrence and progression of prostate cancer (c-Myc, AR, AR-V7, KLK3, KLK2, TMPRSS2). XYD113 exhibits anticancer activity against prostate cancer. XYD113 can be used in the research of prostate cancer. | |||||||||||||||||||||
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Keywords
