3032451-58-1
3032451-58-1
Chemical Structure
PARP1/2-IN-3
- CAS No.: 3032451-58-1
- Formula:C26H21FN6O3
- Molecular Weight:484.48
InChIKey: QDPSJQULHBXXHG-UHFFFAOYSA-N
SMILES: CC1=CC=C(O1)C2=NN=C3CN(CCN32)C(C4=CC(CC5=NNC(C6=C5C=CC=C6)=O)=CC=C4F)=O
Biological Activity: PARP1/2-IN-3 (Compound 29) is an orally active inhibitor for PARP 1 and PARP 2 with IC50 of 0.2235 nM and <0.001 nM. PARP1/2-IN-3 inhibits the proliferation of Capan-1 wildtype, AZD2281 or BMN673 resistant cells with IC50 of 1.82-9.98 nM. PARP1/2-IN-3 exhibits antitumor efficacy in mice[1].
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PARP1/2-IN-3 | PARP1/2-IN-3 (Compound 29) is an orally active inhibitor for PARP 1 and PARP 2 with IC50 of 0.2235 nM and <0.001 nM. PARP1/2-IN-3 inhibits the proliferation of Capan-1 wildtype, AZD2281 or BMN673 resistant cells with IC50 of 1.82-9.98 nM. PARP1/2-IN-3 exhibits antitumor efficacy in mice. | |||||||||||||||||||||
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References
Keywords
