PARP1/2-IN-3
PARP1/2-IN-3 (Compound 29) is an orally active inhibitor for PARP 1 and PARP 2 with IC50 of 0.2235 nM and <0.001 nM. PARP1/2-IN-3 inhibits the proliferation of Capan-1 wildtype, AZD2281 or BMN673 resistant cells with IC50 of 1.82-9.98 nM. PARP1/2-IN-3 exhibits antitumor efficacy in mice.
For research use only. We do not sell to patients.
- CAS No.: 3032451-58-1
- Formula: C26H21FN6O3
- Molecular Weight:484.48
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
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PARP-1 0.2235 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CAPAN-1 | IC50 |
1.82 nM
Compound: 2
|
Antiproliferative activity against human CAPAN-1 cells assessed as cell proliferation inhibition incubated for 7 days by SRB assay
Antiproliferative activity against human CAPAN-1 cells assessed as cell proliferation inhibition incubated for 7 days by SRB assay
|
[PMID: 37605459] |
| CAPAN-1 | IC50 |
8.28 nM
Compound: 2
|
Antiproliferative activity against human Olaparib-resistant CAPAN-1 cells assessed as cell proliferation inhibition incubated for 7 days by SRB assay
Antiproliferative activity against human Olaparib-resistant CAPAN-1 cells assessed as cell proliferation inhibition incubated for 7 days by SRB assay
|
[PMID: 37605459] |
| CAPAN-1 | IC50 |
9.98 nM
Compound: 2
|
Antiproliferative activity against human Talazoparib-resistant CAPAN-1 cells assessed as cell proliferation inhibition incubated for 7 days by SRB assay
Antiproliferative activity against human Talazoparib-resistant CAPAN-1 cells assessed as cell proliferation inhibition incubated for 7 days by SRB assay
|
[PMID: 37605459] |
Chemical Information
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CAS No. 3032451-58-1
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Molecular Weight 484.48
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Formula C26H21FN6O3
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SMILES
CC1=CC=C(O1)C2=NN=C3CN(CCN32)C(C4=CC(CC5=NNC(C6=C5C=CC=C6)=O)=CC=C4F)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)